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Target
Histone deacetylase 8
Ligand
BDBM50350236
Substrate
n/a
Meas. Tech.
ChEMBL_761697 (CHEMBL1816689)
IC50
90±n/a nM
Citation
 Whitehead, L; Dobler, MR; Radetich, B; Zhu, Y; Atadja, PW; Claiborne, T; Grob, JE; McRiner, A; Pancost, MR; Patnaik, A; Shao, W; Shultz, M; Tichkule, R; Tommasi, RA; Vash, B; Wang, P; Stams, T Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg Med Chem 19:4626-34 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50350236
Synonyms:
CHEMBL1812335
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O
Mol. Mass.:
335.228
SMILES:
N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1Cc2ccccc2C1 |r|
Structure:
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