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Target
Thymidylate kinase
Ligand
BDBM50359620
Substrate
n/a
Meas. Tech.
ChEMBL_793312 (CHEMBL1931815)
Ki
45000±n/a nM
Citation
 Van Poecke, S; Munier-Lehmann, H; Helynck, O; Froeyen, M; Van Calenbergh, S Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorg Med Chem 19:7603-11 (2011) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50359620
Synonyms:
CHEMBL1928430
Type:
Small organic molecule
Emp. Form.:
C18H17ClF3N7O4
Mol. Mass.:
487.82
SMILES:
Cc1cn([C@H]2C[C@H](Nc3nnnn3-c3ccc(Cl)c(c3)C(F)(F)F)[C@@H](CO)O2)c(=O)[nH]c1=O |r|
Structure:
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