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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50047009
Substrate
n/a
Meas. Tech.
ChEMBL_795920 (CHEMBL1936793)
IC50
2000000±n/a nM
Citation
 Smith, JR; Evans, KJ; Wright, A; Willows, RD; Jamie, JF; Griffith, R Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. Bioorg Med Chem 20:1354-63 (2012) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50047009
Synonyms:
1-Methyl-9H-beta-carbolin-7-ol | 1-Methyl-9H-beta-carbolin-7-ol (harmalol) | 1-methyl-9H-pyrido[3,4-b]indol-7-ol | CHEMBL14285 | CHEMBL1535235
Type:
Small organic molecule
Emp. Form.:
C12H10N2O
Mol. Mass.:
198.2206
SMILES:
Cc1nccc2c3ccc(O)cc3[nH]c12
Structure:
Search PDB for entries with ligand similarity: