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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50334158
Substrate
n/a
Meas. Tech.
ChEMBL_799943 (CHEMBL1941649)
Ki
0.590000±n/a nM
Citation
 Maisonial, A; Grosse Maestrup, E; Wiese, C; Hiller, A; Schepmann, D; Fischer, S; Deuther-Conrad, W; Steinbach, J; Brust, P; Wünsch, B Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for centrals1 receptors and comparison with fluoroalkyl homologs. Bioorg Med Chem 20:257-69 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50334158
Synonyms:
1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine | CHEMBL1645202 | CHEMBL2314421
Type:
Small organic molecule
Emp. Form.:
C21H24FNO
Mol. Mass.:
325.4198
SMILES:
FCCC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Structure:
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