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Target
5-hydroxytryptamine receptor 3A/3B
Ligand
BDBM50366369
Substrate
n/a
Meas. Tech.
ChEMBL_3239 (CHEMBL618925)
Ki
328±n/a nM
Citation
 Langlois, M; Soulier, J; Mathe-Allainmat, M; Gallais, C; Bremont, B; Shen, S N-chloromethyl quinuclidinium derivatives: A new class of irreversible ligands for 5-HT3 receptors. Bioorg Med Chem Lett 4:945-948 (1994)    Article 
Target
Name:
5-hydroxytryptamine receptor 3A/3B
Synonyms:
Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 2974
Components:
This complex has 2 components.
Component 1
Name:
5-hydroxytryptamine receptor 3B
Synonyms:
5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor
Type:
PROTEIN
Mol. Mass.:
50328.78
Organism:
Rattus norvegicus
Description:
EBI_11885
Residue:
437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
  
Component 2
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50366369
Synonyms:
CHEMBL1744070
Type:
Small organic molecule
Emp. Form.:
C20H21ClN3O2
Mol. Mass.:
370.852
SMILES:
Nc1ccc2C(=O)N([C@@H]3C[N+]4(CCl)CCC3CC4)C(=O)c3cccc1c23 |r,wU:8.7,(1.8,-11.08,;3.13,-10.3,;3.12,-8.75,;4.45,-7.98,;5.78,-8.74,;7.11,-7.96,;7.09,-6.43,;8.44,-8.73,;9.77,-7.96,;11.11,-8.73,;12.44,-7.96,;13.55,-9.03,;15.03,-8.61,;11.61,-6.65,;10.52,-7.75,;9.76,-6.41,;11.09,-5.64,;12.44,-6.41,;8.45,-10.27,;9.8,-11.04,;7.12,-11.06,;7.12,-12.59,;5.78,-13.36,;4.44,-12.59,;4.45,-11.04,;5.78,-10.27,)|
Structure:
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