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Target
Beta-3 adrenergic receptor
Ligand
BDBM50147443
Substrate
n/a
Meas. Tech.
ChEBML_38782
EC50
537±n/a nM
Citation
 Dow, RL; Paight, ES; Schneider, SR; Hadcock, JR; Hargrove, DM; Martin, KA; Maurer, TS; Nardone, NA; Tess, DA; DaSilva-Jardine, P Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists. Bioorg Med Chem Lett 14:3235-40 (2004) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50147443
Synonyms:
CHEMBL110969 | N'-[4-(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]-N-methyl,N-cyclohexylsulfamide
Type:
Small organic molecule
Emp. Form.:
C23H32ClN3O3S
Mol. Mass.:
466.036
SMILES:
CN(C1CCCCC1)S(=O)(=O)Nc1ccc(CCNC[C@H](O)c2cccc(Cl)c2)cc1
Structure:
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