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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50023702
Substrate
n/a
Meas. Tech.
ChEBML_138792
IC50
250±n/a nM
Citation
 Sauerberg, P; Falch, E; Meier, E; Lembøl, HL; Krogsgaard-Larsen, P Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem 31:1312-6 (1988) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50023702
Synonyms:
5-Methyl-3-prop-2-ynyloxy-6,7-dihydro-4H-thiopyrano[3,4-d]isoxazol-5-ium; iodide | CHEMBL284208
Type:
Small organic molecule
Emp. Form.:
C10H12NO2S
Mol. Mass.:
210.272
SMILES:
C[S+]1CCc2onc(OCC#C)c2C1
Structure:
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