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Target
Neprilysin
Ligand
BDBM50042834
Substrate
n/a
Meas. Tech.
ChEBML_144597
IC50
209±n/a nM
Citation
 MacPherson, LJ; Bayburt, EK; Capparelli, MP; Bohacek, RS; Clarke, FH; Ghai, RD; Sakane, Y; Berry, CJ; Peppard, JV; Trapani, AJ Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem 36:3821-8 (1994) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rattus norvegicus (Rat)
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50042834
Synonyms:
9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid (3-hydroxy-propyl)-amide | CHEMBL339629
Type:
Small organic molecule
Emp. Form.:
C14H26N2O3S
Mol. Mass.:
302.433
SMILES:
OCCCNC(=O)C1CCCCCCC(CS)C(=O)N1
Structure:
Search PDB for entries with ligand similarity: