Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50066912
Substrate
n/a
Meas. Tech.
ChEMBL_58649 (CHEMBL666363)
Ki
160±n/a nM
Citation
 Campiani, G; Nacci, V; Bechelli, S; Ciani, SM; Garofalo, A; Fiorini, I; Wikström, H; de Boer, P; Liao, Y; Tepper, PG; Cagnotto, A; Mennini, T New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure. J Med Chem 41:3763-72 (1998) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50066912
Synonyms:
(+/-)9-(4-Methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | (R)-(-)9-(4-Methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | (S)-(+)9-(4-Methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene(ST1622) | 9-(4-Methyl-piperazin-1-yl)-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene | CHEMBL333246
Type:
Small organic molecule
Emp. Form.:
C17H21N3S
Mol. Mass.:
299.434
SMILES:
CN1CCN(CC1)C1Cn2cccc2Sc2ccccc12
Structure:
Search PDB for entries with ligand similarity: