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Target
Adenosine receptor A3
Ligand
BDBM50149359
Substrate
n/a
Meas. Tech.
ChEMBL_31707 (CHEMBL644951)
Ki
83±n/a nM
Citation
 Colotta, V; Catarzi, D; Varano, F; Calabri, FR; Lenzi, O; Filacchioni, G; Martini, C; Trincavelli, L; Deflorian, F; Moro, S 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. J Med Chem 47:3580-90 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50149359
Synonyms:
6-Amino-2-(4-methoxy-phenyl)-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione | CHEMBL333016
Type:
Small organic molecule
Emp. Form.:
C16H13N5O3
Mol. Mass.:
323.3061
SMILES:
COc1ccc(cc1)-n1nc2n(c3cccc(N)c3[nH]c2=O)c1=O
Structure:
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