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Target
Acyl-CoA desaturase 1
Ligand
BDBM50371052
Substrate
n/a
Meas. Tech.
ChEMBL_438936 (CHEMBL889279)
IC50
505±n/a nM
Citation
 Liu, G; Lynch, JK; Freeman, J; Liu, B; Xin, Z; Zhao, H; Serby, MD; Kym, PR; Suhar, TS; Smith, HT; Cao, N; Yang, R; Janis, RS; Krauser, JA; Cepa, SP; Beno, DW; Sham, HL; Collins, CA; Surowy, TK; Camp, HS Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. J Med Chem 50:3086-100 (2007) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50371052
Synonyms:
CHEMBL229254
Type:
Small organic molecule
Emp. Form.:
C27H29BrN4O3
Mol. Mass.:
537.448
SMILES:
COc1ccc(Br)c(c1)C(=O)N1CCN(CC1)c1ccc(cn1)C(=O)NCCCc1ccccc1
Structure:
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