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Target
D(2) dopamine receptor
Ligand
BDBM50169842
Substrate
n/a
Meas. Tech.
ChEMBL_454646 (CHEMBL886666)
Ki
310±n/a nM
Citation
 Wilson, KJ; van Niel, MB; Cooper, L; Bloomfield, D; O'Connor, D; Fish, LR; MacLeod, AM 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. Bioorg Med Chem Lett 17:2643-8 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50169842
Synonyms:
1-(2,4-difluorophenethyl)-4-fluoro-4-(4-fluorophenylsulfonyl)piperidine | 1-[2-(2,4-Difluoro-phenyl)-ethyl]-4-fluoro-4-(4-fluoro-benzenesulfonyl)-piperidine | CHEMBL175832
Type:
Small organic molecule
Emp. Form.:
C19H19F4NO2S
Mol. Mass.:
401.418
SMILES:
Fc1ccc(cc1)S(=O)(=O)C1(F)CCN(CCc2ccc(F)cc2F)CC1
Structure:
Search PDB for entries with ligand similarity: