Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50374265
Substrate
n/a
Meas. Tech.
ChEMBL_469192 (CHEMBL932218)
Ki
1.2±n/a nM
Citation
 Young, RJ; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chan, C; Charbaut, M; Convery, MA; Diallo, H; Hortense, E; Irving, WR; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Pateman, AJ; Patikis, AN; Pinto, IL; Pollard, DR; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Zhou, P Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs. Bioorg Med Chem Lett 18:28-33 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50374265
Synonyms:
CHEMBL257862
Type:
Small organic molecule
Emp. Form.:
C24H25ClFN5O4S2
Mol. Mass.:
566.068
SMILES:
Fc1cc(ccc1N1CCC(NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)-n1ccnc1CN1CCOCC1 |w:10.11|
Structure:
Search PDB for entries with ligand similarity: