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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50265153
Substrate
n/a
Meas. Tech.
ChEMBL_497084 (CHEMBL997720)
Ki
2000±n/a nM
Citation
 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO Kinase array design, back to front: biaryl amides. Bioorg Med Chem Lett 18:5285-9 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50265153
Synonyms:
CHEMBL501431 | N-(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C32H37N5O3
Mol. Mass.:
539.6679
SMILES:
CCCCn1c(=O)[nH]c2cc(ccc2c1=O)-c1cc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)ccc1C
Structure:
Search PDB for entries with ligand similarity: