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Target
Cyclin-dependent kinase 2
Ligand
BDBM50265154
Substrate
n/a
Meas. Tech.
ChEMBL_497086 (CHEMBL998564)
IC50
>20000±n/a nM
Citation
 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO Kinase array design, back to front: biaryl amides. Bioorg Med Chem Lett 18:5285-9 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50265154
Synonyms:
CHEMBL521734 | N-cyclopropyl-3-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-7-yl)-4-methylbenzamide
Type:
Small organic molecule
Emp. Form.:
C22H22N4O2
Mol. Mass.:
374.4357
SMILES:
Cc1ccc(cc1-c1ccc2c(c1)nnn(CC1CC1)c2=O)C(=O)NC1CC1
Structure:
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