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Target
72 kDa type IV collagenase
Ligand
BDBM50267841
Substrate
n/a
Meas. Tech.
ChEMBL_563473 (CHEMBL961021)
IC50
55300±n/a nM
Citation
 Li, X; Wang, J; Li, J; Wu, J; Li, Y; Zhu, H; Fan, R; Xu, W Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I). Bioorg Med Chem 17:3053-60 (2009) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50267841
Synonyms:
(R)-5-Oxo-5-4-[(1,3-thiazole-2-amino)sulfonyl]phenylamino-4-[(3,4,5-trimethoxybenzamido)amino]pentanoic acid | CHEMBL486063
Type:
Small organic molecule
Emp. Form.:
C24H26N4O9S2
Mol. Mass.:
578.615
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N[C@H](CCC(O)=O)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1 |r|
Structure:
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