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Target
Cyclin-dependent kinase 4
Ligand
BDBM50306874
Substrate
n/a
Meas. Tech.
ChEMBL_608664 (CHEMBL1067150)
IC50
1420±n/a nM
Citation
 Hegde, VR; Borges, S; Pu, H; Patel, M; Gullo, VP; Wu, B; Kirschmeier, P; Williams, MJ; Madison, V; Fischmann, T; Chan, TM Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. Bioorg Med Chem Lett 20:1384-7 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50306874
Synonyms:
8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[1,2,3-cd]indol-5-one | CHEMBL609040 | SCH-535270
Type:
Small organic molecule
Emp. Form.:
C16H9NO4
Mol. Mass.:
279.247
SMILES:
Oc1cccc2c1cc1NC(=O)c3cc4OCOc4c2c13
Structure:
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