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Target
Aurora kinase A
Ligand
BDBM50306874
Substrate
n/a
Meas. Tech.
ChEMBL_608665 (CHEMBL1067151)
IC50
2140±n/a nM
Citation
 Hegde, VR; Borges, S; Pu, H; Patel, M; Gullo, VP; Wu, B; Kirschmeier, P; Williams, MJ; Madison, V; Fischmann, T; Chan, TM Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. Bioorg Med Chem Lett 20:1384-7 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50306874
Synonyms:
8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[1,2,3-cd]indol-5-one | CHEMBL609040 | SCH-535270
Type:
Small organic molecule
Emp. Form.:
C16H9NO4
Mol. Mass.:
279.247
SMILES:
Oc1cccc2c1cc1NC(=O)c3cc4OCOc4c2c13
Structure:
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