Reaction Details Report a problem with these data
Target
Galanin receptor type 1
Ligand
BDBM50415433
Substrate
n/a
Meas. Tech.
ChEMBL_610349 (CHEMBL1072081)
Ki
34200±n/a nM
Citation
 Robertson, CR; Scholl, EA; Pruess, TH; Green, BR; White, HS; Bulaj, G Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery. J Med Chem 53:1871-5 (2010) [PubMed]  Article 
Target
Name:
Galanin receptor type 1
Synonyms:
GAL1-R | GALNR | GALNR1 | GALR1 | GALR1_HUMAN | Galanin R1 | Galanin receptor 1 | Galanin receptor type 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38976.60
Organism:
Homo sapiens (Human)
Description:
Galanin R1 GALR1 HUMAN::P47211
Residue:
349
Sequence:
MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
  
Inhibitor
Name:
BDBM50415433
Synonyms:
CHEMBL1187471
Type:
Small organic molecule
Emp. Form.:
C51H60N10O11
Mol. Mass.:
989.0825
SMILES:
COC(=O)[C@H](CCCCN)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc1oc2C)C(=O)NCC1CCCCC1)C(=O)NC1c2ccccc2-c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: