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Target
Caspase-3
Ligand
BDBM50338495
Substrate
n/a
Meas. Tech.
ChEMBL_728312 (CHEMBL1687572)
IC50
136±n/a nM
Citation
 Jiang, Y; Hansen, TV Isatin 1,2,3-triazoles as potent inhibitors against caspase-3. Bioorg Med Chem Lett 21:1626-9 (2011) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50338495
Synonyms:
(S)-1-((1-(biphenyl-4-yl)-1H-1,2,3-triazol-5-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione | CHEMBL1683182
Type:
Small organic molecule
Emp. Form.:
C29H27N5O5S
Mol. Mass.:
557.62
SMILES:
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(Cc3cnnn3-c3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1 |r|
Structure:
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