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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50390769
Substrate
n/a
Meas. Tech.
ChEMBL_835705 (CHEMBL2071816)
IC50
>10000±n/a nM
Citation
 Jiao, X; Kopecky, DJ; Fisher, B; Piper, DE; Labelle, M; McKendry, S; Harrison, M; Jones, S; Jaen, J; Shiau, AK; Escaron, P; Danao, J; Chai, A; Coward, P; Kayser, F Discovery and optimization of a series of liver X receptor antagonists. Bioorg Med Chem Lett 22:5966-70 (2012) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50390769
Synonyms:
CHEMBL2070370
Type:
Small organic molecule
Emp. Form.:
C27H26F3NO4S
Mol. Mass.:
517.56
SMILES:
COc1cccc(c1)C#CC(O)(c1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccccc1)C(F)(F)F
Structure:
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