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Target
HTH-type transcriptional regulator EthR
Ligand
BDBM50395184
Substrate
n/a
Meas. Tech.
ChEMBL_859797 (CHEMBL2169625)
EC50
340±n/a nM
Citation
 Flipo, M; Willand, N; Lecat-Guillet, N; Hounsou, C; Desroses, M; Leroux, F; Lens, Z; Villeret, V; Wohlkönig, A; Wintjens, R; Christophe, T; Kyoung Jeon, H; Locht, C; Brodin, P; Baulard, AR; Déprez, B Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. J Med Chem 55:6391-402 (2012) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator EthR
Synonyms:
ETHR_MYCTU | HTH-type transcriptional regulator EthR | Transcriptional repressor EthR (EthR) | etaR | ethR
Type:
Protein
Mol. Mass.:
23751.94
Organism:
Mycobacterium tuberculosis
Description:
P9WMC1
Residue:
216
Sequence:
MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR
  
Inhibitor
Name:
BDBM50395184
Synonyms:
CHEMBL2164319
Type:
Small organic molecule
Emp. Form.:
C22H15N3O2S
Mol. Mass.:
385.438
SMILES:
O=C(COc1cccc(c1)C#N)Nc1ccc(cc1)-c1nc2ccccc2s1
Structure:
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