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Target
Cathepsin S
Ligand
BDBM50400186
Substrate
n/a
Meas. Tech.
ChEMBL_878614 (CHEMBL2189084)
IC50
>100000±n/a nM
Citation
 Moreira, DR; Costa, SP; Hernandes, MZ; Rabello, MM; de Oliveira Filho, GB; de Melo, CM; da Rocha, LF; de Simone, CA; Ferreira, RS; Fradico, JR; Meira, CS; Guimarães, ET; Srivastava, RM; Pereira, VR; Soares, MB; Leite, AC Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice. J Med Chem 55:10918-36 (2012) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50400186
Synonyms:
CHEMBL2180341
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2S
Mol. Mass.:
367.465
SMILES:
CCC1SC(=NN=C(C)COc2ccccc2)N(C1=O)c1ccccc1 |w:6.5,4.17|
Structure:
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