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Target
Thyroid hormone receptor beta
Ligand
BDBM18903
Substrate
n/a
Meas. Tech.
ChEMBL_447974 (CHEMBL898226)
IC50
794.33±n/a nM
Citation
 Liu, H; Gramatica, P QSAR study of selective ligands for the thyroid hormone receptor beta. Bioorg Med Chem 15:5251-61 (2007) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM18903
Synonyms:
2-[3,5-dibromo-4-(2-ethylbutoxy)phenyl]acetic acid | 3,5-Dibromo-4-alkoxyphenylalkanoic Acid, 9f
Type:
Small organic molecule
Emp. Form.:
C14H18Br2O3
Mol. Mass.:
394.099
SMILES:
CCC(CC)COc1c(Br)cc(CC(O)=O)cc1Br
Structure:
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