Reaction Details Report a problem with these data
Target
Cytochrome P450 2D6
Ligand
BDBM50437760
Substrate
n/a
Meas. Tech.
ChEMBL_973419 (CHEMBL2410298)
IC50
>10000±n/a nM
Citation
 De Savi, C; Waterson, D; Pape, A; Lamont, S; Hadley, E; Mills, M; Page, KM; Bowyer, J; Maciewicz, RA Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg Med Chem Lett 23:4705-12 (2013) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50437760
Synonyms:
CHEMBL2409676
Type:
Small organic molecule
Emp. Form.:
C19H21F3N6O6S
Mol. Mass.:
518.467
SMILES:
C[C@]1(CS(=O)(=O)N2CCN(CC2)c2ncc(OCc3ccc(o3)C(F)(F)F)cn2)NC(=O)NC1=O |r|
Structure:
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