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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50445026
Substrate
n/a
Meas. Tech.
ChEMBL_1281878 (CHEMBL3101031)
IC50
>100000±n/a nM
Citation
 Zhang, F; Wen, Q; Wang, SF; Shahla Karim, B; Yang, YS; Liu, JJ; Zhang, WM; Zhu, HL Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory. Bioorg Med Chem Lett 24:90-5 (2013) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50445026
Synonyms:
CHEMBL3098271
Type:
Small organic molecule
Emp. Form.:
C13H8Cl2N6S
Mol. Mass.:
351.214
SMILES:
Clc1ccc(C=Nn2c(n[nH]c2=S)-c2cnccn2)c(Cl)c1 |w:6.6|
Structure:
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