Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50068450
Substrate
n/a
Meas. Tech.
ChEMBL_1443747 (CHEMBL3371720)
Ki
3.9±n/a nM
Citation
 Xu, R; Lord, SA; Peterson, RM; Fergason-Cantrell, EA; Lever, JR; Lever, SZ Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorg Med Chem 23:222-30 (2014) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50068450
Synonyms:
1-[2-(2-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)-piperazine | CHEMBL147779
Type:
Small organic molecule
Emp. Form.:
C22H30N2O
Mol. Mass.:
338.4864
SMILES:
COc1ccccc1CCN1CCN(CCCc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: