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Target
Reverse transcriptase
Ligand
BDBM50058298
Substrate
n/a
Meas. Tech.
ChEMBL_1454138 (CHEMBL3362905)
IC50
73400±n/a nM
Citation
 Sancineto, L; Iraci, N; Barreca, ML; Massari, S; Manfroni, G; Corazza, G; Cecchetti, V; Marcello, A; Daelemans, D; Pannecouque, C; Tabarrini, O Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands. Bioorg Med Chem 22:4658-66 (2014) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50058298
Synonyms:
CHEMBL3327281
Type:
Small organic molecule
Emp. Form.:
C26H26N8O4
Mol. Mass.:
514.5358
SMILES:
CCN1c2ncccc2NC(=O)c2cc(NCCNc3cc4n(C)cc(C(O)=O)c(=O)c4cc3N)cnc12
Structure:
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