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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
Ligand
BDBM50101970
Substrate
n/a
Meas. Tech.
ChEMBL_1479101 (CHEMBL3436077)
IC50
26±n/a nM
Citation
 Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol 32:858-66 (2012) [PubMed]  Article 
Target
Name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:
CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:
PROTEIN
Mol. Mass.:
19518.62
Organism:
Cavia porcellus
Description:
ChEMBL_106600
Residue:
169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
  
Inhibitor
Name:
BDBM50101970
Synonyms:
CHEMBL463726
Type:
Small organic molecule
Emp. Form.:
C31H36N2O6S
Mol. Mass.:
564.692
SMILES:
COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)CCc2ccc(OC)c(OC)c2)C(=O)[C@@H]1OC(C)=O |r|
Structure:
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