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Target
Cyclin-dependent kinase 5
Ligand
BDBM50235342
Substrate
n/a
Meas. Tech.
ChEMBL_1655482 (CHEMBL4004952)
IC50
480±n/a nM
Citation
 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem 60:1746-1767 (2017) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50235342
Synonyms:
CHEMBL319467 | NU-6102
Type:
Small organic molecule
Emp. Form.:
C18H22N6O3S
Mol. Mass.:
402.471
SMILES:
NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1
Structure:
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