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Target
Neuronal acetylcholine receptor subunit alpha-9
Ligand
BDBM50049750
Substrate
n/a
Ki
320±n/a nM
Comments
PDSP_218
Citation
 Mukhin, AG; Gündisch, D; Horti, AG; Koren, AO; Tamagnan, G; Kimes, AS; Chambers, J; Vaupel, DB; King, SL; Picciotto, MR; Innis, RB; London, ED 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-9 (2000) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-9
Synonyms:
ACHA9_RAT | Acra9 | Cholinergic, Nicotinic Muscle | Chrna9 | NACHR alpha 9 | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54522.69
Organism:
RAT
Description:
Cholinergic, Nicotinic Muscle 0 RAT::P43144
Residue:
479
Sequence:
MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
  
Inhibitor
Name:
BDBM50049750
Synonyms:
(S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Azetidin-2-ylmethoxy)-pyridine | A-159470 | A-85380 | CHEMBL59986
Type:
Small organic molecule
Emp. Form.:
C9H12N2O
Mol. Mass.:
164.2044
SMILES:
C(Oc1cccnc1)[C@@H]1CCN1 |r|
Structure:
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