Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89068
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
59720±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89068
Synonyms:
4-chlorobenzoic acid [(Z)-[amino-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylidene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-[4-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]amino] ester | MLS-0454737.0001 | [(Z)-[amino-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]amino] 4-chloranylbenzoate | cid_9580892
Type:
Small organic molecule
Emp. Form.:
C20H13ClF3N3O3
Mol. Mass.:
435.784
SMILES:
NC(=NOC(=O)c1ccc(Cl)cc1)c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |w:2.2|
Structure:
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