Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM102293
Substrate
n/a
Meas. Tech.
FLIPR Assay
pH
7.4±0
Ki
14±n/a nM
Citation
 Badiger, S; Behnke, D; Betschart, C; Chaudhari, V; Cotesta, S; Hinrichs, JH; Ofner, S; Pandit, C; Wagner, J Diaza-spiro[5.5]undecanes US Patent  US8530648 Publication Date 9/10/2013 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM102293
Synonyms:
US8530648, 230
Type:
Small organic molecule
Emp. Form.:
C28H30N4O
Mol. Mass.:
438.564
SMILES:
Cc1cc(nc2ccccc12)N1CCC2(CCCN(Cc3c[nH]c4ccccc34)C2=O)CC1
Structure:
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