Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM118171
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3.8±n/a nM
Comments
extracted
Citation
 Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent  US8653125 Publication Date 2/18/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mouse
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM118171
Synonyms:
US8653125, Ia-4
Type:
Small organic molecule
Emp. Form.:
C22H21ClFN5O2
Mol. Mass.:
441.886
SMILES:
Fc1ccccc1-n1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)NC(=O)c2cccc(Cl)n2)n1 |r,wU:17.21,14.14,(7.08,-.52,;7.85,-1.85,;9.39,-1.85,;10.16,-3.18,;9.39,-4.52,;7.85,-4.52,;7.08,-3.18,;5.54,-3.18,;4.64,-4.43,;3.17,-3.95,;3.17,-2.41,;1.84,-1.64,;.51,-2.41,;.51,-3.95,;-.83,-1.64,;-.83,-.1,;-2.16,.67,;-3.49,-.1,;-3.49,-1.64,;-2.16,-2.41,;-4.83,.67,;-6.16,-.1,;-6.16,-1.64,;-7.5,.67,;-8.83,-.1,;-10.16,.67,;-10.16,2.21,;-8.83,2.98,;-8.83,4.52,;-7.5,2.21,;4.64,-1.94,)|
Structure:
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