Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM123907
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
8±n/a nM
Comments
extracted
Citation
 Masuda, K; Kida, S; Yoshikawa, N; Katou, M; Kato, T; Nakajima, M; Kojima, E; Yonehara, M Oxadiazole derivative having endothelial lipase inhibitory activity US Patent  US8754113 Publication Date 6/17/2014 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM123907
Synonyms:
US8754113, I-3-48
Type:
Small organic molecule
Emp. Form.:
C21H19N5O3S
Mol. Mass.:
421.472
SMILES:
O=C(Cc1nnc(Cc2nc3ccc(cc3s2)C2=CCOCC2)o1)NC1(CC1)C#N |t:19|
Structure:
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