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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM131780
Substrate
n/a
Meas. Tech.
Depletion Assay
pH
7.5±n/a
IC50
2±n/a nM
Citation
 Burger, M; Lan, J; Lindvall, M; Nishiguchi, G; Tetalman, M PIM kinase inhibitors and methods of their use US Patent  US8829193 Publication Date 9/9/2014 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM131780
Synonyms:
US8829193, 57
Type:
Small organic molecule
Emp. Form.:
C22H22F2N4O2S
Mol. Mass.:
444.497
SMILES:
C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1csc(n1)-c1c(F)cc(O)cc1F |r|
Structure:
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