Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM131892
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
IC50
12±n/a nM
Comments
extracted
Citation
 Lee, J; Seo, HJ; Kang, SY; Park, E; Kim, MJ; Lee, SH; Kim, JY; Kim, J; Jung, ME; Kim, HJ; Kim, M; Han, HK; Ahn, KW; Lee, MW; Lee, K; Pae, AN; Park, W Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same US Patent  US8835436 Publication Date 9/16/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM131892
Synonyms:
US8835436, Example 103
Type:
Small organic molecule
Emp. Form.:
C28H36ClN5O
Mol. Mass.:
494.071
SMILES:
Cc1nc(C(=O)NCCCCN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1Cl |(-7.07,-3.08,;-6.44,-4.49,;-4.93,-4.81,;-4.77,-6.34,;-3.44,-7.11,;-3.44,-8.65,;-2.1,-6.34,;-.77,-7.11,;.56,-6.34,;1.9,-7.11,;3.23,-6.34,;4.56,-7.11,;5.9,-6.34,;7.23,-7.11,;7.23,-8.65,;5.9,-9.42,;4.56,-8.65,;8.57,-9.42,;8.57,-10.96,;9.9,-11.73,;11.23,-10.96,;11.23,-9.42,;12.57,-8.65,;9.9,-8.65,;9.9,-7.11,;-6.18,-6.96,;-6.5,-8.47,;-7.21,-5.82,;-8.74,-5.98,;-9.65,-4.74,;-11.18,-4.9,;-11.8,-6.3,;-10.9,-7.55,;-9.37,-7.39,;-8.46,-8.63,)|
Structure:
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