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Target
Sodium-dependent serotonin transporter
Ligand
BDBM131891
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
IC50
12±n/a nM
Comments
extracted
Citation
 Lee, J; Seo, HJ; Kang, SY; Park, E; Kim, MJ; Lee, SH; Kim, JY; Kim, J; Jung, ME; Kim, HJ; Kim, M; Han, HK; Ahn, KW; Lee, MW; Lee, K; Pae, AN; Park, W Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same US Patent  US8835436 Publication Date 9/16/2014 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM131891
Synonyms:
US8835436, Example 100
Type:
Small organic molecule
Emp. Form.:
C28H37N5O3
Mol. Mass.:
491.6251
SMILES:
COc1ccccc1-n1c(C)nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(C)c2C)c1C |(-3.59,-10.98,;-4.5,-9.73,;-6.03,-9.89,;-6.66,-11.3,;-8.19,-11.46,;-9.09,-10.22,;-8.47,-8.81,;-6.93,-8.65,;-6.31,-7.24,;-7.08,-5.91,;-8.61,-5.75,;-6.05,-4.76,;-4.64,-5.39,;-3.31,-4.62,;-3.31,-3.08,;-1.97,-5.39,;-.64,-4.62,;.69,-5.39,;.69,-6.93,;2.03,-4.62,;3.36,-5.39,;4.7,-4.62,;6.03,-5.39,;6.03,-6.93,;4.7,-7.7,;3.36,-6.93,;7.36,-7.7,;7.36,-9.24,;8.7,-10.01,;10.03,-9.24,;10.03,-7.7,;11.36,-6.93,;8.7,-6.93,;8.7,-5.39,;-4.8,-6.92,;-3.66,-7.95,)|
Structure:
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