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Target
Coagulation factor VII
Ligand
BDBM189412
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
7.4±n/a
Ki
3330±n/a nM
Comments
extracted
Citation
 Zhang, X; Glunz, P; Priestley, ES; Johnson, JA; Wurtz, NR; Ladziata, V Macrocyclic factor VIIa inhibitors US Patent  US9174974 Publication Date 11/3/2015 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM189412
Synonyms:
US9174974, Comparator 1
Type:
Small organic molecule
Emp. Form.:
C31H32FN5O5S
Mol. Mass.:
605.68
SMILES:
CC(C)S(=O)(=O)c1ccc2NC(=O)OCCc3ccc(cc3)[C@@H](Nc3cc(F)c4c(N)nccc4c3)C(=O)N(C)Cc1c2 |r|
Structure:
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