Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Ligand
BDBM194492
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
1700±300 nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015
More Info.:
Target
Name:
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms:
HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ
Type:
Protein
Mol. Mass.:
26352.14
Organism:
Plasmodium falciparum
Description:
P20035
Residue:
231
Sequence:
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL