Reaction Details Report a problem with these data
Target
Kallikrein-1
Ligand
BDBM200059
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
5000±n/a nM
Citation
 Evans, DM; Davie, RL; Edwards, HJ; Rooker, DP Benzylamine derivatives as inhibitors of plasma kallikrein US Patent  US9234000 Publication Date 1/12/2016 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM200059
Synonyms:
US9234000, 50
Type:
Small organic molecule
Emp. Form.:
C28H39N5O3
Mol. Mass.:
493.641
SMILES:
NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC2CCCCC2)NCC(N)=O)cc1
Structure:
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