Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1 [1-322]
Ligand
BDBM50166435
Substrate
n/a
Meas. Tech.
PTP1B Activity Assay
pH
7±0
Ki
2.4e+3±n/a nM
IC50
4.8e+3± 2e+2 nM
Citation
 Punthasee, P; Laciak, AR; Cummings, AH; Ruddraraju, KV; Lewis, SM; Hillebrand, R; Singh, H; Tanner, JJ; Gates, KS Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate. Biochemistry 56:2051-2060 (2017) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-322]
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B)
Type:
Enzyme
Mol. Mass.:
37368.76
Organism:
Homo sapiens (Human)
Description:
Human PTP1B truncation (1-322 aa)
Residue:
322
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNG
  
Inhibitor
Name:
BDBM50166435
Synonyms:
5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE | 5-(4-Methoxy-biphenyl-3-yl)-1,1-dioxo-1lambda*6*-[1,2,5]thiadiazolidin-3-one | 5-(4-Methoxy[1,1'-biphenyl]-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-Dioxide (2a) | CHEMBL193233
Type:
Small organic molecule
Emp. Form.:
C15H14N2O4S
Mol. Mass.:
318.348
SMILES:
COc1ccc(cc1N1CC(=O)NS1(=O)=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: