Reaction Details Report a problem with these data
Target
Oxysterol-binding protein 2 [1-181,275-916]
Ligand
BDBM20182
Substrate
n/a
Meas. Tech.
Sterol-Binding Assay
pH
7.4±n/a
Temperature
293.15±n/a K
Kd
23±0.0 nM
Comments
extracted
Citation
 Charman, M; Colbourne, TR; Pietrangelo, A; Kreplak, L; Ridgway, ND Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. J Biol Chem 289:15705-17 (2014) [PubMed]  Article 
Target
Name:
Oxysterol-binding protein 2 [1-181,275-916]
Synonyms:
KIAA1664 | ORP4 | OSBP-related protein 4 (ORP4S) | OSBP2 | OSBP2_HUMAN | OSBPL4
Type:
Protein
Mol. Mass.:
90653.30
Organism:
Homo sapiens (Human)
Description:
Human ORP4 truncated variant with no PH domain (Δ182-274)
Residue:
823
Sequence:
MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF
  
Inhibitor
Name:
BDBM20182
Synonyms:
(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol | 25-Hydroxycholesterol (25OH) | 25-hydroxycholesterol
Type:
Small organic molecule
Emp. Form.:
C27H46O2
Mol. Mass.:
402.6529
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@]([H])(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O |r,t:9|
Structure:
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