Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM406496
Substrate
n/a
Meas. Tech.
Intracellular cAMP Accumulation Assay
EC50
5.5±n/a nM
Citation
 Johnson, JA; Kim, S 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists US Patent  US10336739 Publication Date 7/2/2019 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM406496
Synonyms:
3-[5-(1,2- benzoxazol-3- ylmethyl)-1,3,4- oxadiazol-2-yl]-5- (2,6- dimethoxyphenyl)- 6-(ethoxymethyl) pyridine-2,4-diol | US10336739, Example 89
Type:
Small organic molecule
Emp. Form.:
C27H26N4O6
Mol. Mass.:
502.5185
SMILES:
CCCCc1nc(O)c(-c2nnc(Cc3noc4ccccc34)o2)c(O)c1-c1c(OC)cccc1OC |(-8.42,-1.05,;-7.08,-1.82,;-5.75,-1.05,;-4.41,-1.82,;-3.08,-1.05,;-3.08,.49,;-1.75,1.26,;-1.75,2.8,;-.41,.49,;.92,1.26,;2.33,.64,;3.36,1.78,;2.59,3.11,;2.99,4.6,;4.47,5,;5.03,6.44,;6.56,6.36,;6.96,4.87,;8.33,4.17,;8.42,2.63,;7.12,1.79,;5.75,2.49,;5.67,4.03,;1.08,2.79,;-.41,-1.05,;.92,-1.82,;-1.75,-1.82,;-1.75,-3.36,;-.41,-4.13,;.92,-3.36,;2.25,-4.13,;-.41,-5.67,;-1.75,-6.44,;-3.08,-5.67,;-3.08,-4.13,;-4.41,-3.36,;-5.75,-4.13,)|
Structure:
Search PDB for entries with ligand similarity: