Reaction Details
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Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Ligand
BDBM422928
Substrate
n/a
Meas. Tech.
R132H IDH1 Enzymatic Assay
IC50
22.0±n/a nM
Citation
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More Info.:
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD
Type:
Protein
Mol. Mass.:
46641.74
Organism:
Homo sapiens (Human)
Description:
Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong.
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
Inhibitor
Name:
BDBM422928
Synonyms:
(4R)-4-(1-Methylethyl)-3-{6-[(3S,5S,7S)-tricyclo[3.3.1.13,7]dec-1-ylcarbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl}-1,3-oxazolidin-2-one | US10508108, Example 119
Type:
Small organic molecule
Emp. Form.:
C28H33N5O3
Mol. Mass.:
487.5933
SMILES:
CC(C)[C@@H]1COC(=O)N1c1ccc2Nc3ncccc3CN(C(=O)[C@]34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c2n1 |r,TLB:32:24:29.30.31:27,THB:25:26:29:33.24.32,25:24:29:26.31.27,22:24:29.30.31:27|