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Target
Tyrosine-protein kinase SYK
Ligand
BDBM365380
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
5.5±n/a nM
Citation
 Bauer, SM; Jia, ZJ; Mehrotra, M; Song, Y; Xu, Q; Huang, W; Venkataramani, C; Rose, JW; Pandey, A Inhibitors of protein kinases US Patent  US10533001 Publication Date 1/14/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM365380
Synonyms:
US10533001, Example 41 | US11414410, Example 41 | US9868729, Example 41
Type:
Small organic molecule
Emp. Form.:
C31H38N8O4
Mol. Mass.:
586.6846
SMILES:
CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(N[C@@H]3CC[C@@H](CC3)NC(=O)OCc3ccccc3)n2)cc1 |r,wU:23.23,26.30,(-14.41,-44.65,;-14.01,-46.14,;-15.35,-46.91,;-12.68,-46.91,;-11.35,-46.14,;-10.01,-46.91,;-10.01,-48.45,;-11.35,-49.22,;-12.68,-48.45,;-8.68,-49.22,;-8.68,-50.76,;-7.34,-51.53,;-6.01,-50.76,;-4.68,-51.53,;-3.34,-50.76,;-2.01,-51.53,;-.68,-50.76,;-.68,-49.22,;.66,-48.45,;1.99,-49.22,;.66,-46.91,;-2.01,-48.45,;-2.01,-46.91,;-3.34,-46.14,;-3.34,-44.6,;-4.68,-43.83,;-6.01,-44.6,;-6.01,-46.14,;-4.68,-46.91,;-7.34,-43.83,;-8.68,-44.6,;-8.68,-46.14,;-10.01,-43.83,;-10.01,-41.77,;-8.23,-40.75,;-8.23,-38.69,;-6.46,-37.67,;-4.68,-38.69,;-4.68,-40.75,;-6.46,-41.77,;-3.34,-49.22,;-6.01,-49.22,;-7.34,-48.45,)|
Structure:
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