Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM433646
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
920±n/a nM
Citation
 Goldby, A; Jenkins, K; Teall, M Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions US Patent  US10562882 Publication Date 2/18/2020 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM433646
Synonyms:
5-[3-(5-Chloro-3-methylpyridin-2-yl)-3-methoxypiperidine-1-carbonyl]-N,N-dimethylpyridazin-3-amine | US10562882, Example 37
Type:
Small organic molecule
Emp. Form.:
C19H24ClN5O2
Mol. Mass.:
389.879
SMILES:
COC1(CCCN(C1)C(=O)c1cnnc(c1)N(C)C)c1ncc(Cl)cc1C
Structure:
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