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Target
Tyrosine-protein kinase SYK
Ligand
BDBM322903
Substrate
n/a
Meas. Tech.
Enzymatic Syk Kinase Activity
IC50
<10±n/a nM
Citation
 Venkatesan, A; Smith, R; Hosahalli, S; Potluri, V; Panigrahi, SK; Basetti, V; Kunta, K Pyrimido-pyridazinone compounds and methods of use thereof US Patent  US10647720 Publication Date 5/12/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM322903
Synonyms:
2-(azepan-1-yl)-4-((4-(4-(2,3- dihydroxypropyl)piperazin-1-yl)phenyl) amino)pyrimido[4,5-d]pyridazin-5(6H)- one | US10183944, Example 273 | US10647720, Ex. # 273
Type:
Small organic molecule
Emp. Form.:
C25H34N8O3
Mol. Mass.:
494.5893
SMILES:
OCC(O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Structure:
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