Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350080
Substrate
n/a
IC50
10.7±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350080
Synonyms:
US10208024, Example 79 | US10766881, Example 79
Type:
Small organic molecule
Emp. Form.:
C27H30Cl2N8O4
Mol. Mass.:
601.484
SMILES:
CCOCCN1CC(C1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-13.46,-4.21,;-11.92,-4.21,;-11.15,-2.87,;-9.61,-2.87,;-8.84,-1.54,;-7.3,-1.54,;-6.21,-.45,;-5.12,-1.54,;-6.21,-2.63,;-3.58,-1.54,;-2.68,-.29,;-1.21,-.77,;-1.21,-2.31,;-2.68,-2.79,;.12,,;.12,1.54,;1.46,2.31,;2.79,1.54,;4.12,2.31,;2.79,,;1.46,-.77,;4.12,-.77,;4.12,-2.31,;5.46,-3.08,;5.46,-4.62,;6.79,-2.31,;8.12,-3.08,;6.79,-.77,;5.46,,;8.12,,;9.46,-.77,;9.46,-2.31,;10.79,,;12.13,-.77,;13.46,,;10.79,1.54,;9.46,2.31,;9.46,3.85,;10.79,4.62,;8.12,1.54,;6.79,2.31,)|
Structure:
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