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Target
Tyrosine-protein kinase ABL1 [64-515]
Ligand
BDBM477803
Substrate
n/a
Meas. Tech.
Biochemical Kinase Assay
IC50
0.360±n/a nM
Citation
 Romero, FA; Kirschberg, TA; Halcomb, R; Xu, Y Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias US Patent  US10889571 Publication Date 1/12/2021 
Target
Name:
Tyrosine-protein kinase ABL1 [64-515]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51539.77
Organism:
Homo sapiens (Human)
Description:
aa 64-515
Residue:
452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
  
Inhibitor
Name:
BDBM477803
Synonyms:
US10889571, Example 149
Type:
Small organic molecule
Emp. Form.:
C22H18ClF2N5O2S
Mol. Mass.:
489.925
SMILES:
C[C@@H]1CCSc2nc3cc(cc(-c4ccn[nH]4)c3n12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r|
Structure:
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